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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Ergotamine
2
V.c
Pleural thickening - Fibrothorax
1
Last update :
10/08/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Bromocriptine
Cabergoline
Dihydroergocristine
Dihydroergocryptine
Dihydroergotamine
Ergonovine
Ergots, ergot alkaloids, ergolines
Methysergide
Nicergoline
Pergolide
Publications
Ergotamine-induced pleural and pericardial effusion successfully treated with colchicine.
Pleural and pericardial fibrosis after ergotamine therapy.
Pleural and pericardial fibrosis after ergotamine therapy.
Pleuropulmonary fibrosis associated with chronic and excessive intake of ergotamine.
[Ergotamine treatment and pleuritis].