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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ergotamine

2

XII.b Valvular heart disease and/or dysfunction

2
Last update : 20/06/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bromocriptine
3
Cabergoline
3
Dihydroergocristine
1
Dihydroergocryptine
1
Dihydroergotamine
1
Ergonovine
1
Ergots, ergot alkaloids, ergolines
4
Methysergide
2
Nicergoline
1
Pergolide
3

Publications

Drug-induced valvular heart disease: an update.
Archives of cardiovascular diseases 2013 May;106;333-9 2013 May
From headache to heartache: ergotamine-induced aortic and mitral valvulopathy.
Journal of the American College of Cardiology 2013 Dec 03;62;2144 2013 Dec 03
Ergotamine-associated valvulopathy with recurrent chylous pleural effusion.
Texas Heart Institute journal 2012;39;736-8 2012
Drug-induced fibrotic valvular heart disease.
Lancet (London, England) 2009 Aug 15;374;577-85 2009 Aug 15
Mitral valve disease associated with long-term ergotamine use.
Southern medical journal 1993 Oct;86;1179-81 1993 Oct

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