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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Ergotamine
2
XII.b
Valvular heart disease and/or dysfunction
2
Last update :
20/06/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bromocriptine
Cabergoline
Dihydroergocristine
Dihydroergocryptine
Dihydroergotamine
Ergonovine
Ergots, ergot alkaloids, ergolines
Methysergide
Nicergoline
Pergolide
Publications
Drug-induced valvular heart disease: an update.
From headache to heartache: ergotamine-induced aortic and mitral valvulopathy.
Ergotamine-associated valvulopathy with recurrent chylous pleural effusion.
Drug-induced fibrotic valvular heart disease.
Mitral valve disease associated with long-term ergotamine use.