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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Mannitol

1

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1
Last update : 06/01/2015
 
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Diagnosing DIRD
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Drug and radiation history
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Drug singularity - Correct identification of the drug
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Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Excipients-Vehicle-Preservatives (of drugs)
5

Publications

Unexpected death: anaphylactic intraoperative death due to Thymoglobulin carbohydrate excipient.
Forensic science international 2013 May 10;228;e28-32 2013 May 10
[A life-threatening anaphylactic reaction following mannitol].
Der Anaesthesist 1992 Mar;41;130-3 1992 Mar
Peranaesthetic anaphylactoid shock due to mannitol.
Allergy 1992 Feb;47;61-2 1992 Feb

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