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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Pembrolizumab
5
XV.d
Path: Acute fibrinous organizing pneumonia (AFOP-pattern) (see also If)
1
Last update :
14/05/2019
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Atezolizumab
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
Ipilimumab
Lambrolizumab
Nivolumab
PD-1/PD-L1-inhibitors or blocking agents/drugs
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