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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Hydrocodone

2

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

1
Last update : 13/04/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

A Benefit Risk Review of Pediatric Use of Hydrocodone/Chlorpheniramine, a Prescription Opioid Antitussive Agent for the Treatment of Cough.
Drugs - real world outcomes 2019 Jun;6;47-57 2019 Jun
Adverse events associated with opioid-containing cough and cold medications in children.
Clinical toxicology (Philadelphia, Pa.) 2018 Nov;56;1162-1164 2018 Nov

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