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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Alectinib

1

XXI.e Rechallenge may not necessarily lead to relapse of AE/ILD

1
Last update : 02/01/2019
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Successful re-introduction of alectinib after inducing interstitial lung disease in a patient with lung cancer.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2019 Sep;25;1531-1533 2019 Sep
Case report: continued treatment with alectinib is possible for patients with lung adenocarcinoma with drug-induced interstitial lung disease.
BMC pulmonary medicine 2017 Dec 06;17;173 2017 Dec 06

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