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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Docetaxel

3

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2
Last update : 09/06/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Paclitaxel
5

Publications

Docetaxel-induced interstitial lung disease among patients with breast cancer: a case series and review of literature.
Respirology case reports 2021 Jul;9;e00802 2021 Jul
Fatal hypersensitivity pneumonitis associated with docetaxel.
Tumori 2013;99;e100-3 2013
Acute interstitial pneumopathy associated with docetaxel hypersensitivity.
Onkologie 2004 Dec;27;563-5 2004 Dec
Severe interstitial pneumonitis associated with docetaxel administration.
Cancer 2002 Feb 01;94;847-53 2002 Feb 01
Life-threatening hypersensitivity pneumonitis induced by docetaxel (taxotere).
British journal of cancer 2001 Nov 02;85;1247-50 2001 Nov 02
[Acute diffuse interstitial pneumopathy following docetaxel (Taxotère). Apropos of 2 cases].
Revue des maladies respiratoires 1998 Apr;15;199-203 1998 Apr

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