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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Docetaxel

3

X.c Capillary leak syndrome (CLS)

1
Last update : 30/04/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Paclitaxel
5

Publications

[Docetaxel-induced acute pulmonary capillary-leak syndrome mimicking cardiogenic oedema].
Annales francaises d'anesthesie et de reanimation 2007 Feb;26;180-1 2007 Feb
Capillary protein leak syndrome appears to explain fluid retention in cancer patients who receive docetaxel treatment.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998 Oct;16;3426-32 1998 Oct

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