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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trastuzumab emtansine (Ado-trastuzumab emtansine - TDM-1)

1

VI.b Pulmonary arterial hypertension

1
Last update : 25/11/2024
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Trastuzumab
5
Trastuzumab deruxtecan
4

Publications

Association of Pulmonary Hypertension With Trastuzumab Emtansine: An Analysis of French Pulmonary Hypertension Registry and WHO Pharmacovigilance Database.
Chest 2024 Nov 19;; 2024 Nov 19

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