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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trastuzumab emtansine (Ado-trastuzumab emtansine - TDM-1)

1

I.b Pneumonitis (ILD)

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Last update : 07/09/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
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Clinical, imaging, BAL, pathological pattern consistent with the specific drug
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Careful exlusion of another cause
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Remission of symptoms with removal of drug
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Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Trastuzumab
5
Trastuzumab deruxtecan
4

Publications

Pneumonitis associated with Trastuzumab emtansine in a patient with metastatic breast cancer.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2022 Apr;28;740-745 2022 Apr
Interstitial pneumonitis associated with trastuzumab emtansine.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2019 Oct;25;1798-1800 2019 Oct
Ado-Trastuzumab Emtansine-Induced Pulmonary Toxicity: A Single-Institution Retrospective Review.
Case reports in oncology 2018;11;527-533 2018

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