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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Trastuzumab emtansine (Ado-trastuzumab emtansine - TDM-1)

1

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

1
Last update : 27/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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See also under
Trastuzumab
5
Trastuzumab deruxtecan
4

Publications

Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010 Jun 01;28;2698-704 2010 Jun 01

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