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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Ibrutinib

2

XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

1
Last update : 25/12/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

Ibrutinib-related atrial fibrillation: Therapeutic challenges.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2019 Jul;25;1258-1260 2019 Jul
Management of adverse effects/toxicity of ibrutinib.
Critical reviews in oncology/hematology 2019 Apr;136;56-63 2019 Apr
Ibrutinib-Associated Atrial Fibrillation.
JACC. Clinical electrophysiology 2018 Dec;4;1491-1500 2018 Dec
Cardiovascular Toxic Effects of Targeted Cancer Therapies.
The New England journal of medicine 2016 Oct 13;375;1457-1467 2016 Oct 13
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia.
The New England journal of medicine 2014 Jul 17;371;213-23 2014 Jul 17
Ibrutinib increases the risk of atrial fibrillation, potentially through inhibition of cardiac PI3K-Akt signaling.
Blood 2014 Dec 11;124;3829-30 2014 Dec 11

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