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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Immunotoxins

2

X.c Capillary leak syndrome (CLS)

2
Last update : 17/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

A phase I study of a combination of anti-CD19 and anti-CD22 immunotoxins (Combotox) in adult patients with refractory B-lineage acute lymphoblastic leukaemia.
British journal of haematology 2011 Aug;154;471-6 2011 Aug
Treatment of therapy-refractory B-lineage acute lymphoblastic leukemia with an apoptosis-inducing CD19-directed tyrosine kinase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999 Dec;5;3906-13 1999 Dec
Phase I trial of an anti-CD19 deglycosylated ricin A chain immunotoxin in non-Hodgkin's lymphoma: effect of an intensive schedule of administration.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1995 Nov;18;231-41 1995 Nov
A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy.
Blood 1993 Nov 01;82;2624-33 1993 Nov 01
Phase I immunotoxin trial in patients with B-cell lymphoma.
Cancer research 1991 Aug 01;51;4052-8 1991 Aug 01

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