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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Diacetyl (2,3-butanedione) flavoring agent

3

IV.c Obliterative bronchiolitis (a pattern consistent with) (see also IVn, XVx)

3
Last update : 09/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
E-cigarette - E-vaporizers - ENDS - Vaping - Dabbing
5
Flavoring agents
5

Publications

Respiratory morbidity in a coffee processing workplace with sentinel obliterative bronchiolitis cases.
American journal of industrial medicine 2015 Dec;58;1235-45 2015 Dec
Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
Occupational and environmental medicine 2014 Aug;71;549-54 2014 Aug
Increased respiratory disease mortality at a microwave popcorn production facility with worker risk of bronchiolitis obliterans.
PloS one 2013;8;e57935 2013
Constrictive bronchiolitis obliterans: the fibrotic airway disorder.
Expert review of respiratory medicine 2007 Aug;1;139-47 2007 Aug
Bronchiolitis obliterans syndrome in popcorn production plant workers.
The European respiratory journal 2004 Aug;24;298-302 2004 Aug

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