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Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

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X.an Cytokine release syndrome - Cytokine storm

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Last update : 07/03/2021

Diagnosing DIRD

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Drug and radiation history

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Drug singularity - Correct identification of the drug

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Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

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Recurrence with rechallenge (rarely advisable)

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Causality assessment

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