Pneumotox » Drug » Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx » XI.ba - Nonrespiratory AE of interest

Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

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XI.ba Nonrespiratory AE of interest

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Last update : 21/04/2019

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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