Pneumotox » Drug » Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx » XII.ba - Sudden cardiac death

Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

5

XII.ba Sudden cardiac death

2

Last update : 28/02/2019

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

More detailed checklist