Pneumotox » Drug » Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx » XVII.e

Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

XVII.e Pneumocystis jiroveci pneumonia

Pneumocystis pneumonia more likely the result of those immunosuppressive drugs used to treat immune-related adverse events from ICIs (PMID 26451305, 30635258)

Last update : 14/01/2019

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

XVII.e Pneumocystis jiroveci pneumonia

Publications