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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

5

XV.e Path: ILD with a granulomatous component (see also Im)

1
Last update : 25/04/2018
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Atezolizumab
2
Avelumab
1
CTLA4 blocking immunotherapy
3
Camrelizumab
1
Ipilimumab
4
Lambrolizumab
4
Nivolumab
5
PD-1/PD-L1-inhibitors or blocking agents/drugs
5
Pedelizumab
1
Pembrolizumab
5
Tislelizumab
1
Tremelimumab
1
Vaccination - Immunization
2
Vaccines
3
Zimberelimab
1

Publications

Clinical and Histopathologic Features of Immune Checkpoint Inhibitor-related Pneumonitis.
The American journal of surgical pathology 2019 Oct;43;1331-1340 2019 Oct
Sarcoid-Like Granulomatosis of the Lung Related to Immune-Checkpoint Inhibitors: Distinct Clinical and Imaging Features of a Unique Immune-Related Adverse Event.
Cancer immunology research 2018 Jun;6;630-635 2018 Jun
Sarcoidosis-Like Reactions Induced by Checkpoint Inhibitors.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2018 Aug;13;1076-1082 2018 Aug
Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2017 Mar;35;709-717 2017 Mar

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