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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

5

X.am Immune-related adverse effect/toxicity

1
Last update : 20/10/2014
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Atezolizumab
2
Avelumab
1
CTLA4 blocking immunotherapy
3
Camrelizumab
1
Ipilimumab
4
Lambrolizumab
4
Nivolumab
5
PD-1/PD-L1-inhibitors or blocking agents/drugs
5
Pedelizumab
1
Pembrolizumab
5
Tislelizumab
1
Tremelimumab
1
Vaccination - Immunization
2
Vaccines
3
Zimberelimab
1

Publications

Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies.
Annals of oncology : official journal of the European Society for Medical Oncology 2015 Dec;26;2375-91 2015 Dec
Checkpoint blocking antibodies in cancer immunotherapy.
FEBS letters 2014 Jan 21;588;368-76 2014 Jan 21
Opportunistic autoimmune disorders: from immunotherapy to immune dysregulation.
Annals of the New York Academy of Sciences 2010 Jan;1183;222-36 2010 Jan

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