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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Adrenaline (epinephrine)
3
II.a
Pulmonary edema, noncardiogenic (NCPE)
2
Last update :
20/01/2012
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
Publications
Adrenaline induced pulmonary oedema.
Acute pulmonary edema after local infiltration of epinephrine during mastoidectomy: A case report.
Lessons for management of anaphylaxis from a study of fatal reactions.
Delayed-onset epinephrine-induced pulmonary edema.
New developments in synthetic bone replacement materials.
Adrenaline-induced pulmonary oedema and its treatment. A report of two cases.