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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Adrenaline (epinephrine)

3

XII.g Coronary artery disease (acute) - Myocardial ischemia/infarction

2
Last update : 05/08/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

ACE-I Angioedema: Accurate Clinical Diagnosis May Prevent Epinephrine-Induced Harm.
The western journal of emergency medicine 2016 May;17;283-9 2016 May
Adrenaline in anaphylaxis treatment. Balancing benefits and harms.
Expert opinion on drug safety 2016 Jun;15;741-6 2016 Jun
Myocardial ischaemia following cocaine and adrenaline exposure in a child during an ophthalmological procedure.
Irish medical journal 2015 Mar;108;89-90 2015 Mar
Epinephrine-induced myocardial infarction in severe anaphylaxis: is nonselective β-blockade a contributory factor?
The American journal of emergency medicine 2013 Apr;31;759.e1-2 2013 Apr
Wandering coronary stenoses: adrenaline-induced coronary artery spasm in a patient resuscitated from cardiac arrest.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2010 Jun 01;75;1056-9 2010 Jun 01
Lessons for management of anaphylaxis from a study of fatal reactions.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2000 Aug;30;1144-50 2000 Aug

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