Pneumotox » Drug » Nicotine

Nicotine

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Last update : 05/12/2013

IV.a Bronchospasm - Wheezing - Asthma

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IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

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XI.b Chest pain (acute or subacute), lone or prominent

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XI.r Death following exposure or poisoning

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XI.bd Nicotine poisoning

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XII.g Coronary artery disease (acute) - Myocardial ischemia/infarction

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XII.l Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

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XII.m Cardiac- cardiorespiratory/pulmonary arrest

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XII.ag Bradycardia

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Diagnosing DIRD

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Drug and radiation history

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Drug singularity - Correct identification of the drug

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Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

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Recurrence with rechallenge (rarely advisable)

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Causality assessment

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