Pneumotox » Drug » Quinine

Quinine

3

Last update : 15/01/2017

I.b Pneumonitis (ILD)

1

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1

I.d Organizing pneumonia pattern (an area or areas of consolidation on imaging)

1

II.a Pulmonary edema, noncardiogenic (NCPE)

1

II.b ARDS - Acute lung injury

1

II.j Transient pulmonary opacities/infiltrates (see also under Iav)

1

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1

III.m Coagulopathy

1

VIII.b Hematoma of/around central airway wall potentially causing UAO

1

VIII.d Thermal (burns, frostbite), chemical or caustic facial and/or airway injury

1

X.a DRES syndrome - DRESS-like reaction

1

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

1

X.h Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

1

X.m Vascultis (pulmonary, extrathoracic or systemic)-ANCA status unknown or negative)

1

X.ad Skin purpura, ecchymoses or necrosis

1

X.af Thrombotic microangiopathy

1

XI.b Chest pain (acute or subacute), lone or prominent

1

XIV.a Methemoglobinemia

1

XV.c Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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