Pneumotox » Drug » Methimazole

Methimazole

2

Last update : 15/04/2012

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1

III.b Pneumorenal syndrome (w/wo ANCAs)

1

III.d Alveolar hemorrhage, diffuse (ANCA-positive/-related)

1

IV.a Bronchospasm - Wheezing - Asthma

1

V.b Eosinophilic pleural effusion

1

VI.d Pulmonary vasculitis or capillaritis

2

VIII.c Upper airway obstruction other than angioedema or hematoma

1

X.e Autoimmunity-Autoimmune conditions (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)

2

X.s Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

1

X.x Subclinical ANCA positivity

1

XI.n Neutropenia, agranulocytosis (w/wo infection/sepsis)

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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