Ventilatory depression (amenable to the antidote naloxone (PMID 26370638) is the most common complication of the substance. Acute, flash pulmonary edema is a classic complication of i.v. heroin. Benzodiazepine and alcohol (ethanol) may be cotoxicants in heroin-associated deaths (PMID 2391481). The development of PAH should raise the suspicion of pill excipient-induced vasculopathy and consequent PHT. Buprenorphine diversion may lead to that complication. A major contribution on PMID 5339228

Last update : 12/11/2017