Pneumotox » Drug » Atezolizumab

Atezolizumab

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Last update : 20/06/2018

I.a Pneumonitis (ILD), acute and/or severe (may cause ARDS)

1

I.b Pneumonitis (ILD)

1

I.k Lung nodule or nodules

1

V.a Pleural effusion (uni- or bilateral) (May commpany ILDs)

1

V.i Pleuritis (can cause chest pain)

1

VII.e Granulomatous mediastinal lymphadenopathy

1

X.d Lupus - Lupus syndrome (see also Vd)

1

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

1

X.k Sarcoid-like granulomatosis (endo-/extrathoracic)

1

X.ae Antisynthetase antibodies (ASA) - ASA syndrome

1

X.am Immune-related adverse effect/toxicity

2

XII.d Myocarditis (can be fulminant)

1

XII.ai Cardiotoxicity

1

XV.ba Path: Granulomatous lymphadenopathy

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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