Pneumotox » Drug » Chlorine gas (dichlorine: Cl2)

Chlorine gas (dichlorine: Cl2)

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See also under PMID 27303906 and 29722341

Last update : 13/07/2021

I.af Chemical (toxic) pneumonitis

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I.ao Pulmonary infiltrates

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II.a Pulmonary edema, noncardiogenic (NCPE)

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II.b ARDS - Acute lung injury

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III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

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III.j Anti-GBM-related pneumorenal syndrome and DAH (Goodpasture) or flare of

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IV.j Bronchiolitis (a clinical-imaging pattern suggestive of)

2

IV.n Obstructive airway dysfunction (see also IVc, XVx)

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IV.q Reactive airway dysfunction syndrome (RADS)

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IV.aj Airway hemorrhage on endoscopy

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VIII.al Epiglottitis

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XV.w Path: Pulmonary edema (see also II/IIa)

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XVI.v Imaging: Centrilobular micronodules (can be diffuse)

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XVI.ai Imaging: A 'tree-in-bud' pattern

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Diagnosing DIRD

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Drug and radiation history

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Drug singularity - Correct identification of the drug

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Consistent timing of exposure v. onset of symptoms

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Clinical, imaging, BAL, pathological pattern consistent with the specific drug

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Careful exlusion of another cause

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Remission of symptoms with removal of drug

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Recurrence with rechallenge (rarely advisable)

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Causality assessment

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